Interview with Dr. Reiss Uzzi, author of Natural Superwoman and specialist in hormone balancing, nutrition and mind/body principles, chats with us about the difference between bio-identical hormone replacement therapy and hormone replacement therapy, benefits of DHEA supplementation, adrenal support protocols, natural birth control options, overcoming amenorrhea, and more.
For podcast transcript, scroll down.
SHOW NOTES + LINKS
- Get the Keto Holiday Cookbook
- More from Dr. Reiss Uzzi
- Get Dr. Uzzi’s book, The Natural Superwoman
- Subscribe on iTunes or your favorite podcast app
- Difference between BHRT and HRT (14:12)
- The best thyroid protocol and meds (27:12)
- Alternatives to birth control (56:46)
- Overcoming amenorrhea (01:01:48)
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TRANSCRIPT FOR THIS EPISODE
Leanne Vogel: You’re listening to episode number eight of The Keto Diet Podcast. Hey, I’m Leanne switching from a sugar burning state to becoming fat burning machines. The keto diet has helped me with fertility, has ended my constant weight struggles, blood sugar irregularities, imbalanced moods, and so, so much more. I want to share this magic with you using a realistic approach to this powerful diet. No restriction, new ways of looking at things, and positive support awaits. Let’s get this party started.
Hey guys! Today is Sunday, and I have been looking forward to this specific interview for like ever, and ever, and ever. Before I get into what we’re going to be chatting about, the awesome thing this week that I have to share with you, and it may seem super simple and ridiculous, but I’ve been carrying around a large, large water bottle. Like, something you would take camping that carries a bunch of liters. I think it’s a four-liter water bottle, and I have just been carrying it around with me all day, all the time. I have been drinking so much more water because of it. It’s got a big huge opening, which means I can chug back as much water as I want in one go.
It’s not my 600 milliliter water bottle, which I love. My sister gave it to me for Christmas, and I love it, but it’s so tiny, and I drink it so quickly, and then I just forget to fill it up. Although, it may be a little bit simple, carrying around a huge water bottle that’s actually not even a bottle, it’s just a big jug of water that you would make juice in, actually helps you drink more water. For reals. I’ve been doing it for weeks and I love it. I wanted to share that awesome thing with you.
Today we are covering off the following items in this episode: the difference between bioidentical hormones and hormone replacement therapy, steps to supporting proper thyroid function, alternatives to birth control, overcoming amenorrhea, and so much more. Basically, all the questions you ever had about hormones are going to be answered. The show notes for today’s episode can be found at healthfulpursuit.com/podcast/e8, and let’s hear from one of our awesome partners before we get started.
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Leanne Vogel: I do have an announcement for you guys for this episode. As I mentioned last week, I just launched my Keto Holiday Cookbook. It’s a digital cookbook. It’s an instant download. It’s only $10. You can get it at healthfulpursuit.com/ketoholiday, and there are over 30 keto recipes to help make your holidays and special occasions low carb, high fat, grain free, dairy free, and paleo. It has a bunch of recommendations on how to make things low FODMAP, nightshade free, nut free, egg free, vegan, vegetarian, and it includes a bunch of Thanksgiving recipes, in addition to an entire dinner party menu for your Thanksgiving festivities. It goes through exactly which recipes to create. It gives you a shopping list for those recipes, and then goes through the macros of each. The macros are super impressive. I’m really happy I was able to stay with the classic ketogenic approach for this book. Really excited to share it with you. Again, that’s healthfulpursuit.com/ketoholiday, and I will include a link in the show notes for that.
If you have an idea for a podcast episode, or you want to submit praise over and above the review that you’re about to leave for the show, you can reach me at firstname.lastname@example.org, and I’m going to read a review that we just got on the show recently. The review comes from Jen4163, and she says, “Leanne, absolutely loving the new podcast so far. You have so much valuable information to share, and even though I don’t follow a keto diet, I still learn something new each episode. Thank you.” That’s so great. That’s really what I wanted to do for The Keto Diet podcast, is create a resource that all women can use. Specifically, those that follow a ketogenic diet, but if you have been listening for a little while, then you know that I’m sharing stuff over and above, and things that will help any woman.
If you want to leave your review and support my show, you can go to healthfulpursuit.com/review and you’ll be directed to the page where you can submit your review. Just click on reviews, and write a review, give me five stars, hopefully, write a little something nice. Or, you can go to your favorite podcast app and search for the keto diet podcast and submit your review there.
So, today’s awesome guest is Dr. Reiss Uzzi, and if you guys don’t know Dr. Reiss Uzzi, I highly recommend heading on over to his website or getting his book. He wrote The Natural Superwoman book in 2008. I read it. I was blown away. A couple of you recommended that he come on the show, so we got him on the show. I’ll just introduce him a little bit, and then we will get started. From the very start of his clinical practice, 20 years ago, Dr. Uzzi Reiss’ objective has been to help patients correct lifestyle mistakes from the past, overcome symptoms in the present, and move forward to a healthier future. He accomplishes this with individualized programs of natural hormones, nutrition, and body-mind principals. At his center, patients have come to him seeking a doctor who does more than prescribe pills for their symptoms. They have come to a doctor who searches for causes of problems and who works with patients to optimize their health.
In 2008 The Natural Superwoman was published. This book is an informative encyclopedia that supplies you with scientific based data on the value, the safety, and the significant benefits of nutrients and natural hormones in our society today, and at any age. He is currently working on a new book titled, The Invisible Woman. You guys submitted so many amazing questions on our private Facebook page, which you gain access to when you purchase any of my keto programs, available at healthfulpursuit.com/shop, and there were so many questions that I had to pick the top one. I tried to pick Dr. Reiss Uzzi’ brain, came up with a bunch of different questions.
I tried to cover off everything from amenorrhea, to perimenopause, to menopause, hormone replacement therapy, bioidentical hormone replacement therapy, the differences, the dangers of certain hormones. We talk about Synthroid and autoimmunity. It was so hard to keep this under an hour. I’m sorry we didn’t, but I hope that you will gain a ton of knowledge on the matter of hormones and I loved how aligned Dr. Reiss Uzzi and I were throughout the conversation. I was nodding my head the whole time and agreed with everything that he was saying. That’s always, to me, a good indication that I’m having a good guest on the show. Somebody that’s going to provide value to you, and somebody that aligns with the experiences that I’ve had in my own health journey. So, without further ado, let’s cut over to the interview.
Hi, Dr. Reiss Uzzi. How are you doing today?
Dr. Reiss Uzzi: Today, I’m doing very good, as every day. Started my day at 5: 30.
Leanne Vogel: Oh my goodness.
Dr. Reiss Uzzi: Did a hard Pilates for one hour, and now I’m ready to go. It’s the first rainy day in Los Angeles, for I think, like six months.
Leanne Vogel: Wow. You guys need it. You guys really need it. For those of you who aren’t familiar with Dr. Reiss Uzzi’ work, I’m wondering, Dr. Reiss Uzzi, if you can tell us a little bit about yourself?
Dr. Reiss Uzzi: Well, originally, I’m obstetrician and gynecologist, but all my life I strongly believe in alternative medicine. From the very beginning of my career, I always look for a solution that is not drug or surgery related, but more nutritionally and naturally hormonal related. I opened the first premenstrual syndrome clinic in the world, was in 1982. Everybody say this guy is crazy. The women that have PMS are crazy. It doesn’t exist. It’s not true. By that time, I started to give bioidentical hormones. It’s something that I use for a long period. The practice is dominant by the use of bioidentical hormone. I mean, we are trying to give women exactly what their body had. Not an alternative. That makes a huge difference.
When I started with only three physicians in the world, they did it. One the Seattle area, myself, and one person in Brussels. Today fortunately, there are 5,000 compounding pharmacy that give to the public bioidentical hormone. It shows the wide acceptance of bioidentical hormone. But in the same time the media, official medicine, the drug administration, all of them are fighting the strength. I don’t want to get to the political reason why. Since then, my practice have evolved. I am doing more and more about finding a nutritional solution. I have been for a nutritional solution for birth control, and very much against the use of birth control pill. I have treatment for fibroid, for endometriosis. I have a lot of supportive treatment for women with breast cancer. I do a lot of work into how women can prevent and what they should do to prevent breast cancer.
Leanne Vogel: There’s lots going on.
Dr. Reiss Uzzi: Basically, every condition that it is treated by drug, medication or surgery, in my practice, I have an alternative solution. Now, I don’t do regular gynecological work. It’s just I treat the situation that people looking for an alternative solution, but I treat the whole gamut of the whole person. The woman is not a breast and vagina. The woman has brain, gut. The gut is an essential tool for immunity, for neurotransmission, for wellbeing, and basically, I addressed condition like fatigue, energy loss, memory. The epidemic of dementia and Alzheimer is incredible. This is a direct result of a generation that doesn’t take hormones. The epidemic of bone loss and this drug solution for bone loss are horrified. Again, this is a generation of women that don’t take hormone.
The increased incidence of insomnia. How many women don’t sleep? Insomnia leads to cancer, depression, anxiety, inability to perform well. Sleeping medication mask the situation, don’t solve it. Again, if women would have bioidentical hormone, they will sleep well, they’ll dream, they’ll sleep deep, they’ll wake up with energy. This is a population of women that have very much higher incidence of cardiovascular disease, stroke. Again, directly related to the fall of our natural hormone. There’s a deterioration of the skin. Do you know, yes, we can stretch with skin, we can spend thousand of dollar putting on this skin cream, but giving to the body its essential hormone, is the number one tool to restore the function of our skin. We’re restoring from inside, not from the outside.
Women social skill improve. Women are depressed today. Antidepressant medication, it was shown, barely work in women that are menopausal. They first have to have their own hormone, and each of the hormone. It’s so much to our mood, and to our mind, and to our motivation, and to our social skill. I can talk on, and on, and on.
Leanne Vogel: About the benefits. I guess there’s a little bit of misconception, I know, probably all women wonder what’s the difference between bioidentical hormones, which is what you’re talking about, and hormone replacement therapy? Because, I’m a woman who was on hormone replacement therapy. It messed me up, but word on the street is that bioidentical hormones are better. Can you explain how that works?
Dr. Reiss Uzzi: What is HRT? It’s a combination of two chemicals. One, they took a pregnant mare, dehydrate them, sedate them, catheterize them, put them in a small stall, take their urine, and make out of it hormone that they’re giving to women. This is the standard estrogen in HRT. An estrogen that were designed to the body of a pregnant mare, but not a human being. I would say, the Premarin, it’s probably a better solution rather than nothing, but you cannot compare its benefit to the benefit of your hormone. Then come a drug that’s called Provera. Provera is a chemicalized progesterone. They, and try to imagine who I mean by they, but they did everything to confuse the public. They cannot call it progesterone because progesterone is a bioidentical hormone. They called it progestogen, progestin, so you’ll get confused, but this is something totally different to what our body do.
The chemicalized progesterone is destructive to the brain. It’s destructive to the mood. It impair our mood. Impair our memory. It’s agitate. It depress. It leach the bone. It cause tremendous about of increase in cardiovascular disorder. It’s aggressively increase breast cancer.
Leanne Vogel: That’s really scary.
Dr. Reiss Uzzi: Comparing the natural progesterone. It’s totally different. I would say human being, a hormone, it calm, relax, helps sleep, behave like natural diuretic, decrease appetite, help women sleep, deepen the sleep, prevent sleep apnea. It’s incredibly protective to the brain. Layer of layer of data, how women that are on progesterone, their likelihood to suffer from the consequence of stoke diminished. How, a woman that have brain trauma, when they are on progesterone, the damage is significantly lower and their recovery is faster. Progesterone build bone, and progesterone is so protective to the breast from so many point of view. The problem starts with that.
Until 19, 2001, most women in the United States, the minute they enter menopause they were given premarin provera. The truth is, if you look at the work of one of the best epidemiologists in this country, her name is Trudy Bush from John Hopkins. Unfortunately, she is dead now. At 2001, she summarized 50 of the best report for 25 year experience for premarin provera. By the way, her first sentence is, it doesn’t increase breast cancer. A year later, came the most traumatic, I would think, event to women in the world, the WHI Study, the Women Health Initiative.
That basically, I will explain to you very quickly, how false it was and how false was the message. The message was HRT, I mean hormonal replacement therapy, that our [inaudible 00: 18: 02] hormone cause breast cancer. The incidence was 28%. I can give you 50 other reason that causes more breast cancer, including taking antibiotic for 50 days in your lifetime or drinking one cup of grapefruit a day. But, that was mal-informed. Those women didn’t enter menopause. Those women were already 10 to 20 year in menopause. Number two, they misrepresent the result. When those women were taking those two hormones, the urinal pregnant mare, and the chemicalized progesterone, they have 28% more breast cancer, but 25% of that population haven’t taken this chemical progesterone that’s aggressively increased breast cancer, and we all know it. This group had 23% less breast cancer. The report of the Women Health Initiative should have been estrogen of the HRT decrease breast cancer, and the chemicalized progesterone increase breast cancer.
Look at that. The Swede registered everything, and immediately after that announcement, use of hormone in treating decrease by 60%. They wait for eight years, and there’s no decline in breast cancer. Then there’s further decrease in the incidence of breast cancer. Excuse me, in an incidence of use of hormone and breast cancer start to go up. They say that doesn’t make sense. They took all the data of the WHI study, and they claim that the statistic in the WHI study, it was intentional to show those results. They claim they use more objective statistic and the result of the same study, with the same data, that there was no increase of breast cancer, even with the two chemicalized hormones.
Another group from South America did the same thing, and again they claimed when you use proper statistic, and not the statistic that intentional to show a specific result, you see no increase in breast cancer. So, the conclusion that women should have taken from this report, that estrogen, that is, the estrogen that comes from the urine of a pregnant mare, it’s safe. But, the problem, those are not our estrogen. Those are estrogen that human being never had. The easiest way to look at hormone and safety, we look at pregnancy. Pregnancy is an avalanche of hormones. This is the Everest of hormone in women body. The two estrogen, one of them go up 1,000 fold. The other one goes up ten fold. Progesterone increase 100 fold. Not 100%, 100 fold. Testosterone go up, human growth hormone go up, and what happen to breast cancer? The women are pregnant, it goes down by 7%.
What happened? The young women with breast cancer would come today to every physician in the United States and will ask him whether they can get pregnant. They will get a horrified story of death before the pregnancy end. But, the reality is, if a young woman with breast cancer gets pregnant, and her body is bombarded by this huge amount of bioidentical hormone, she lives twice as long, and the likelihood to have long distance metastasis and death decrease by 50%. The message, as it was given, was not a correct, and wrong. One of the known scientists look only at this small group of women that had a hysterectomy and didn’t take the premarin and calculate that between 20 to 100,000 women die early because they were not using the hormone. What about the rest of the population?
The story is a story of safety, and the reality is, when a woman come to you, she has two question. Would I die from breast cancer, or would I gain weight I answer something about the first question, but about the weight gain issue. Have you seen many women in menopause that don’t take the hormone that doesn’t gain weight? The minute women enter into menopause; they have changes in the function of the mitochondria. The mitochondrion is an engine that pushes the function of every organ in the body. In the minute this engine doesn’t work, the body slow down, metabolism slows down, fat go up, physical condition collect resistancy that make weight loss even more difficult. My answer to those women are always going on bioidentical hormone will decrease the rate of weight gain that all of them had experience.
For example, estrogen increases satiety, the feeling of fullness of in the body. It decrease a hormone called ghrelin makes you very hungry. Again, the metabolism goes up. The body tendency to build muscle go up. The body tendency to lose fat increase. The tendency to diabetes decrease. The mood is better. We are not depressed and need to eat a lot of carb to lift our mood. We don’t stay up all night, nervous and can’t sleep, and eat. The two main question that women usually ask, will I gain weight, will I die from breast cancer. I think the data don’t support negative affect. Again, even the chemicalized estrogen had shown the women that used it has a lower incidence of breast cancer.
Leanne Vogel: It sounds like chemical based, while it’s not ordeal, the bioidentical stuff is definitely ideal to go on. Is that right? More of the chemical based …
Dr. Reiss Uzzi: Yes, and many other. The chemical based estrogen is in a pill. First, it increase inflammation in the body. It is not good. Number two, it increases in the body a system that holds hormone, so the minute you use it, you decrease your other hormone. For example, bioidentical estrogen decrease the dryness in the eyes. The chemicalized estrogen increase the dryness in eyes. The bioidentical estrogen improves the condition of the bladder. The chemicalized estrogen doesn’t do this. The chemicalized estrogen protects the cardiovascular system. The chemicalized estrogen don’t protect the cardiovascular system. There are layers and layers of hormones that are designed to impregnate a mare and to substitute what our body needs. I’m not going even, to the point of a horrified abuse of those horses, that get sedated, catheterized, dehydrated.
Leanne Vogel: It sounds horrible.
Dr. Reiss Uzzi: Mine you, pregnant women, I keep you in a small bathroom, lock the door, give you a catheter, barely give you eat, don’t give you to drink water. How horrified it is?
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Leanne Vogel: Would the same rules apply for say, thyroid? Because I can’t tell you how many people in my own practice, women that have been on Synthroid forever, and the difference between Synthroid, Naturthroid, desiccated thyroid. Would it be assumed that the desiccated would be best?
Dr. Reiss Uzzi: You know, I’ve seen at least 140,000 that I gave them different hormone. There’s only one, only one that I can state did better with chemicalized thyroid. But here is the issue, the issue is not so much the type of thyroid that I give to you. It’s the system, how we measure thyroid function. When I start medical school in 1972, when they taught me then about thyroid, we had not tested thyroid. Thyroid was already given for 120 years. They taught me, ask, touch her hand. If the hand are dry, if the hand are cold, if they’re losing the outside third of her eyebrow. If she losing hair, if she wake up slowly, if she wake up stiff, if she doesn’t sweat, if she depressed in the morning, if she is gaining weight, if she is constipated, she has thyroid deficiency.
Today, you go to somebody, look at your result and tell you if you have thyroid deficiency or not. It’s absurd, because of the normal, the so-called normal is between the lowest 2.5% of the population to the highest 97.5% of the population. So, mind you, all your life you were in the 80th percentile, and now you drop to the lowest 5th percentile. You’re still normal. It’s ridiculous.
Leanne Vogel: Yeah. I agree with you.
Dr. Reiss Uzzi: The decision has to be mainly clinical. Also, the thyroid doesn’t have just one hormone, which called T4, that this is the Synthroid. The Synthroid is only small portion of efficiency. It moves into T3 that’s way more effective. By the way, it also moves to T2, that is in charge of weight loss now. We know that so many conditions interfere with the movement of the T4 to the T3, and especially when you take Synthroid, the body make another hormone in large quantity that’s called reverse T3, that sabotage T3. So, if you don’t look for T3, and in the blood level the T3 is good, but the woman have every sign of low thyroid. Usually you find out that she has very high reverse T3 that don’t let your T3 work. For me, it’s first clinical appearance.
Let us say I will be wrong. Let us say I would give to a woman minimum amount of thyroid, and I always start with everything as low as I can, but you can never predict how somebody will respond. We have different genomic and some people response fast. Some people respond so slow. What would be this horrified thing that will happen, that happen 1 in 100 times, that I was wrong, and a woman don’t need this thyroid? For one day, she will feel a little bit irritable, agitated, nervous. Okay. With one out of 100 that I try to add it because she has symptomatology, she will not use it, but 99 other men and women will improve so significantly.
Finally, they jump out of bed. They don’t feel stiff. They don’t have to be grouchy for half an hour before they feel like normal human being. They can sweat. Their skin is soft. Their hair are growing. Their nail are growing. Their bowel movement is softer. They maintain their weight. You know, one of the most important thing when it come to Synthroid, that you are talking, is it have very long half life. When you take it the morning of the test, it appear like you have so much more than you really have. You always, if you take Synthroid, you shouldn’t take the thyroid the morning of a test. Not only that, that latest report show that if you take the Synthroid at night, your body have ability to form more T3 and it’s more useful.
There’s one thing left that I don’t have yet to answer. I’m totally confused and conflicted about it. What do you do with autoimmune thyroid disease? Because, there’s some indirect data that maybe natural thyroid maybe a little bit more offensive to people that have autoimmune thyroid disease, but I haven’t developed yet a complete opinion about it.
Leanne Vogel: That’s really interesting. I think for any of these therapies, it sounds like what you’re saying is a hormone protocol is more of a life long approach that’s then changed as needed. Is it safe? I think I know the answer to this already, but is it safe to be on these therapies forever?
Dr. Reiss Uzzi: Well, you make a choice. First, by the way … Well, here come the holistic approach to medicine. You see somebody with thyroid disorder. They’re obese, they’re tired, they’re depressed, they lose hair, etc., etc., etc. You check the number, and that obviously confirm it. For me, confirm it, you don’t have to be … you can be in the 10th percentile and so-called within normal limit, but still you need thyroid. Then I question myself. What happen in her body that she lost the thyroid function. Number one, poor gut and inflammation lead to it. We need to look at the gut. Number two, iodine deficiency lead to thyroid deficiency. Selenium deficiency, selenium deficiency, it such important factor that lead to thyroid deficiency.
When it come to autoimmune thyroid, again, leaky gut, the presence of a parasite can do it. People that eat a tremendous amount of cruciferous, for example, they will have lower the conversion of T4 to T3 lead to sign of thyroid deficiency. People that are stressful, it leads to some degree of thyroid deficiency. You have to look at the whole body. Women on birth control pill, and here I’ll mention something, the modern solution, oh bioidentical hormone are not good. Chemicalized hormone are not good. They put them on birth control. You see women in their 50 given this junk. This too chemical that have nothing to do with our body. They deliver no hormone, suppress the ability of the brain to make no hormone, increase significantly thromboembolic phenomenon. Clots, heart attack.
When women take birth control pill the body increase a substance called sex binding globulin. Sex-binding globulin, it’s our hormonal life overhead. Decide how much the body give to you, and how much your body hold way from you. In the minute that you use the pill, the body take a lot of your thyroid away. By the way, not only the thyroid, the growth hormone, the cortisol, the DHEA, every other hormone from your body. Just when you switch them off the birth control pill, suddenly within six weeks they have enough thyroid because the body don’t hold it anymore. We always have to think how to replace, why it’s happened, what we can do to prevent it. Especially in an autoimmune disease, if you can control the autoimmune phenomena that led to the thyroid deficiency, you could theoretically come to the point that the person don’t need anymore thyroid medication.
Leanne Vogel: In the case of low hormones, like we talked about thyroid, and the reasons why thyroid would be low. What are the reasons why something like your sex hormones or cortisol would be low?
Dr. Reiss Uzzi: You’re talking about … what do you mean by sex hormone?
Leanne Vogel: Estrogen, progesterone. In my own experience, for example, it looked like a light switch had gone off in my body, like no hormones were being created.
Dr. Reiss Uzzi: We are in an era … you see, it’s … I’m 71. I would say it’s one good thing to be older because I have been giving women hormones since 1982. At that time, it was the effect of the horrified chemicalized environment on women and men hormone was totally different. In the last 40 years, there is 70 to 80% decline in the level of hormone in our society. Male get more feminized. Men lose testosterone, lose DHEA, lose human growth hormone, lose DHEA, lose pregnenolone, and the estrogen goes up. Look at this generation of 20 years older. Half of them, I don’t know. I’m looking for the men, and I can see young men with more estrogen than testosterone. I’m a small man, but my level of testosterone at 50 was three time as high, and the level of testosterone in a young man today.
The same for women. They go into menopause much earlier. The women go into menopause even in late 30. Women that try to reserve the egg in mid-30, many of them have problem. They may not gone into menopause, but the body produce so much less estrogen. The normal, you cannot trust the normal, because the normal is normal in people of bankruptcy. You look at the average of society of income of people in United States and you measure only the people on welfare. Most of the population is in hormonal bankruptcy. Finally, somebody have normal hormone, they tell you you have too much. We need to use clinics, clinical symptoms to understand.
If I see a 20 year old woman that she’s not in menopause, she’s not in perimenopause, and she come and tell us she barely bleeds. She’s depressed, flat, uninspired, unmotivated, cannot sleep, feel hot at night, have dry vagina, dry eyes, foggy, uninspired, unmotivated and those symptoms exacerbate. When usually, if estrogen go down, is a week or 10 days before her period, or during her period. You don’t need much. She has estrogen deficiency. It doesn’t matter she’s not in menopause, and you add her bioidentical hormone, and you turn around her life. It’s so important to always look at clinical finding. If you don’t sleep, you’re depressed, you have night sweats, you don’t have enough estrogen. Point.
Leanne Vogel: Where does DHEA fall in all of that?
Dr. Reiss Uzzi: Again, we are in an area of DHEA bankruptcy. DHEA used to be the highest level hormone in the body of women and men. Women were around 600; men were around 800. If you look at the scientific article from the 60, they’ll say it never go down before mid-40, and stop to go down by mid-60. Remember, DHEA, anti-autoimmune, anti-inflammatory, antiviral, anticancer, antidepressive, mood elevator, adaptogen, help us to adapt to the environment around us. Let us feel better in a higher elevation. Let us feel better at a lower elevation. Now a day, you see the most minimal level of DHEA in even young people. The only population of women that relatively have a higher level of DHEA, is women with polycystic ovarian syndrome, and it was shown, it’s the body trying to protect the cardiovascular system. DHEA is an essential hormone. It does so much. It hurts so little, and it’s so predictive because when you give DHEA, you know exactly what is going to happen.
You know exactly what is going to be the sign when you take too much, and you go down in the dose. You have no side effect in DHEA, but it turns to testosterone and gives you oily skin, or it’s agitated, so you can so safely start to give it, increase it slowly until, I believe, you have to reach the point that you cannot go up. Because, the number is so low, and again, different people will respond differently. When it come to men, most of them can use 50 mg. That toxic report over 100 mg. Most women can use about 10 mg. Very few can take 50, but this is an essential hormone. This is a power house to sustain the adrenal that is so weakened in our society because people are so stressed. It’s probably one of the best anti-stress hormones, but it doesn’t work immediately. You are not going to take DHEA today, and you’re going to be not stressed tomorrow, but in few weeks it will have incredible effect on you.
Leanne Vogel: Speaking from somebody who takes DHEA, this stuff has changed my life. I’m on the 10 mg and it’s amazing.
Dr. Reiss Uzzi: You know, many time it also change the life of women because it’s enhance the level of estrogen in the body. I always suggest women, always go to the point that you know you cannot take it. If you go from 10 to 15 for example, and in the coming two weeks you’re not agitated, you don’t have oily skin, it’s mean you can tolerate 15. Then you see if you can tolerate 20. Most can tolerate between 10 and 15 mg.
Leanne Vogel: Yeah, I did 20 once and I was so angry.
Dr. Reiss Uzzi: What kind of DHEA? Where did it coming from? How pure is it? Micronized DHEA has a higher absorption rate. We prescribe DHEA in a suppository that we put it in the entrance to the vagina, because it both tightens the vagina, because it enhances muscular activity, and both lubricate the vagina because of the estrogen that it give. Some women do not tolerate DHEA pills. Cream, I think you have to use so much in order to achieve something, but in small quantity, DHEA cream is wonderful to the skin, and improve the quality of the skin.
Leanne Vogel: Speaking about more to do with supplementation and such, what is your stance on things like Maca or Vitex to support hormone balance?
Dr. Reiss Uzzi: You ask me difficult question.
Leanne Vogel: Okay.
Dr. Reiss Uzzi: I don’t want to sound ostentatious. Why I should take Vitex when I can give progesterone. Do you understand? Why, but, understand. I see women with small symptomatology. They rather make the body work better, so I would use Vitex to substitute progesterone. Maca is more complex. Do you know what, if I would be Inca Indian in the mountain in Peru, would take Maca. On that population, it worked very well, but the Maca, also, when I try to give hormone to women on Maca, they’re still not responding. They won’t respond well because it blocks their receptor. It cover the receptor. This is in effect that it is smaller, milder. I will go to it in the very, very, very few that end up to need so little.
There are some men and women, their body absorb hormone so fast and deactivate it so slow, so the best way to go to them is the indirect way by Maca or Vitex. I use more Vitex than Maca. The Maca is more complex. It affect a lot of hormone in the body. When you have the real stuff, why not to use the real stuff? Do you understand? That’s my question, because progesterone have wider effect, more known effect.
Leanne Vogel: It might be a good strategy say, if somebody’s hormones are pretty balanced and it’s in addition to their bioidentical hormone replacement therapy?
Dr. Reiss Uzzi: No, then you can screw it up. I’m sorry, because you compete on a receptor. Do you understand? Those together, it’s not a good idea. You first use … Now, it’s not true that when you give bioidentical hormone, you make the body lazy to produce it. It’s not true. Let’s take estrogen. When you start HRT with a women that has slowed down her estrogen production, whether she’s still in perimenopause, or menopause, or even younger, by giving them bioidentical estrogen, you improve the ability of the body to make more estrogen. That will happen until 58. After 58 you won’t do it. Many time adding estrogen make it so the body can produce more estrogen. So many time women in perimenopause, I’ll give them a little bit of estrogen, and then a few weeks later they don’t need it or few weeks. Because the body improve its production. In general, hormone, bioidentical hormone, never interfere negatively with our body production.
Leanne Vogel: But the chemical will.
Dr. Reiss Uzzi: Beside natural cortisone. When you give natural cortisone, over certain amount, which you should never give, then the adrenal glands start to make less. We never take over the body by giving bioidentical hormone. We either add, or even improve the function. When I give you DHEA, do you know how many hormone improve? Estrogen improve. Testosterone improve. DHEA improve. Now you’re more calm. You’re more relaxed. Your cortisone getting better balanced. You make be able to produce more pregnenolone the same time. Do you understand?
Leanne Vogel: Yeah, and so the chemical based approach is to hormone therapy in a lot of ways could quiet the body in making their own. Is that correct?
Dr. Reiss Uzzi: Yeah. Should be abandoned. With chemicalized progesterone provera should be abandoned. A drug that kill your breasts, that destroy your brain, destroy your bone, agitate you, create significantly havoc on the cardiovascular system, why we still give it? Why we still give something like this? I was reviewing the literature, and just give you an example, they talk about antidepressive drug by the name of Paxil. The article say, is it a villain that should be abandoned? No, it’s not so bad. Well, it’s not so bad. It increase breast cancer by 600%.
If you are on Tamoxifen and you take Paxil, you death improve by 100%. Why such a drug should be available at all? When there’s so … and by the way, it has a whole gamut of other horrified side effects. Why? Why is shouldn’t be taken out of the market?
Leanne Vogel: In the case of adrenal disfunction, I have a little bit of history of supplementing with hydrocortisone. I’m now off of it. What are the steps that one can take to support their adrenals hormonally with bioidentical hormones or what not. Like, we spoke about DHEA and how that can support the adrenals. Is hydrocortisone a bad approach, or what’s a better approach?
Dr. Reiss Uzzi: Listen, I can tell my life story. There’s a period of my time, I don’t do it for 20 years now. I did obstetrics. I did obstetrics here, in Beverly Hill. I never left a woman in labor, so when I labor will go into labor I will stay there until she delivered, and end up working 120 hours a week. How long it took until I collapse, and one day couldn’t wake up in the morning, and my cortisone was in the bottom? The adrenal gland is a life line gland. If I remove adrenal of the strongest man on earth, he will die in 48 hour. An average person will die in 24 hour. We all horrified by the name cortisol, but most of the cortisone they are given are chemicals. The adrenal hormone make natural hydrocortisone, and we can’t function without it.
I wouldn’t get to the technology how to diagnose, but if you have adrenal deficiency, and Westernized medicine understand one adrenal deficiency. It’s Addison’s disease. You die in few months if you don’t supplement. I’m not talking about this extreme like Kennedy have, but most of us have sub-function, not optimal function, and because of that we overwhelm. We get everything tired us, fatigue us. We can’t tolerate noise. We can’t tolerate any change. We crave a lot of sweet. We feel dizzy easily. When that point come, we have to do two things. First, we have to give essence of life of adrenal gland, and we need to give natural hydrocortisone in order to start to function, not to further suppress activity.
We usually, we have to remember that natural hydrocortisone work for four to six hour, so we need to adjust it according to your activity. If you’re going to exercise, you’re going to take much more than if you sit on a desk all day long. While you’re doing that, you have to start to build back the environment that the adrenal will recover from the period of suppressive stress, and will start to produce more of its own hormone. We do it by giving glandular that are not active, by giving different herb that is an adaptogen, which enhances adrenal function. Maybe a little bit of licorice that kick the cortisone a little higher. I can tell you, there are periods that I was totally dependent on hydrocortisone, and as I got better, I got off that.
I remember one day, I was on the beach in Hawaii, and everybody is running. I said, hey, I used to run. I can run. I’m strong, and I started to run. I ran or one hour and felt so good about myself, but a week later my cortisone was zero because I overdid it. I had to start again to take cortisone. It’s a lifelong balance where there ere periods that you need to add some bioidentical cortisone or just support it with, indefinitely, DHEA and pregnenolone, a strong supporter of the the adrenal gland. There is adrenal hormone, but also then we want to help our adrenal gland, we have to abstain with condition, like stress, and insomnia, and agitation that will further deteriorate the function of our adrenal. It’s not just the supplement. You have to create the environment that helps the body to heal in the same time, and maybe you won’t need those supplement, and that’s very typical to the adrenal.
But, not to the ovary. When you reach 58, there’s not one ovary on this planet that can produce any estrogen. When you enter complete menopause, there’s not one ovary on the planet that produce progesterone. You have to add them.
Leanne Vogel: A lot of doctors will prescribe a birth control to do this. What are your thoughts about that?
Dr. Reiss Uzzi: I think it’s the most horrified, horrified thing I ever seen. Do you know, there’s a data of thinning of brain tissue? It doesn’t give anything. Because, it has no hormone. Maybe, maybe, I would say, the birth control of the 60s that had a lot of estrogen, they gave to women some estrogen, but this is anti-estrogen hysteria, that I call it the most chauvinistic act ever in the United States. Basically claiming that women hormone is horror. They started to do the following that minimized to minimum, the level of the chemicalized estrogen in the birth control pill.
Here, if you really look at it, these young girl they’re depressed, they have dry vagina, they have dry eye, they have significant memory loss. They have decreased in their ability to learn, to reason, to remember, to retain, to retrieve, and in the same time, they increase the intensity of the variety of chemicalized progesterone that’s so nasty to the body. They, not only that they increase breast cancer significantly, they reawaken cancer that was pronounced dead already. They destroy the cardiovascular system. They agitate. They make you retain water. They make you hungry. They destroy your bone. So tell me, why women, why it would ever should be given to women?
This is the one, I usually don’t write prescription, but I respect prescription that somebody use. That, I refuse to write. I wouldn’t write prescription for birth control pills. Something that take young girl, and give them a stroke? Why it should be available at all?
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Leanne Vogel: In the beginning of our recording you mentioned nutritional solutions for birth control, so if somebody is perimenopause, or in the reproductive years, what are some steps that they can take if birth control is no good?
Dr. Reiss Uzzi: Perimenopause, the likelihood that they’ll get pregnant is wishful. Okay? Unfortunately. What I do, is we basically have only four systems. Withdrawal, that don’t work. Using different form of barrier, like rubber or diaphragm, by the way, the diaphragm work just because of the gel that it’s anti-spermicidal, but this anti-spermicidal gel will enter your abdominal cavity from the uterus, and I’m horrified to think how it will irritate and how it will affect the body. Then there is IUD. It’s invasive system, and especially with IUD that have chemicalized progesterone, that even the Scandinavians that produce it had shown it increased breast cancer. What I do, I use bioidentical progesterone to create birth control like environment.
By the way, 50 years ago, Greenwald, one of the most known endocrinologists in the country, registrate it as a patent for birth control, never use it. I take young women at any age, and rather that she would have the progesterone being produced in the last two weeks of her cycle, after she ovulate. I give it around the clock. I usually give … because what I want to achieve, I want to achieve that the lining of the uterus will be paper thin. I give progesterone as suppository. By the way, the minute you put progesterone in suppository, you eliminate the mucus. There’s no mucus. Progesterone eliminates the mucus. If you use it before ovulation, there’ll be no mucus, and we use progesterone in cream during the day.
The truth is that it take a period of 10 to 12 week of totally irregular bleeding until they come to the point that they don’t bleed at all. They don’t bleed, not because we affected their hormone, their hormone are ongoing, and they’re perfect without any disturbance. We eliminate the thickness of the lining of the uterus. The uterus lining is paper thin. Nothing can be implanted, nothing can get in. I do it for at least 30 years. A few thousand women that I did it with them. I don’t recall even one to conceive, and it will work on about 95 out of 100. With 5% the system is not comfortable to them, but it’s a beautiful system that gives you a birth control environment, by the way, will suppress any ability to have endometriosis because the lining is thin. The minute that you want to conceive, you stop It. Just as sudden, you return to normal [suplicity 01: 00: 01].
Leanne Vogel: That’s amazing. That totally blows my mind.
Dr. Reiss Uzzi: But, nobody’s going to use it. Nobody’s going to use it. You can’t patent it. You know what, you cannot make money out of it. It’s not going to be used.
Leanne Vogel: It’s unfortunate that that’s the state.
Dr. Reiss Uzzi: People that deal with bioidentical hormones, that’s a good way for them to use it. Especially the need to apply the progesterone at night, deep vaginally. Because deep vaginally, it go to cervical artery that leaded first of the uterus, and that’s how it create the thinning of the lining of the uterus.
Leanne Vogel: I love that strategy. I can’t … That I know is going to help so many people.
Dr. Reiss Uzzi: That’s the incredible surge of endometriosis, you’ll see beside that I give a lot of antiinflammatory in different way. This will heal the symptomatology, the pain, the abnormal bleeding. It’s very good. The same thing, fibroids, endometriosis. They all come, by the way, fibroid, endometriosis, breast cancer, uterine cancer, they all come from one origin, is a subtype of estrogen. This is not the estrogen that we give to women that call for hydroxyestrone, and estradiol. Those are the most viscous estrogen in our body. Nobody look at them. I can see a woman with breast cancer, that they frighten the hell out of her from estrogen, but she is full of for hydroxyestrone, and estradiol. There are ways for us to work on the system, diminish them, and convert them to type of estrogen that are not as aggressive.
Leanne Vogel: In the case of amenorrhea, there seems to be a huge problem. As somebody who’s suffered from amenorrhea for eight years, I wrote a blog post about it a couple of years ago, and was surprised at how many women don’t get a period. What are the steps that one can take to get it back using your …
Dr. Reiss Uzzi: The first, number one, the number one villain for that is birth control pill. Okay? The birth control suppress the body so much so it doesn’t wake up. What you talking about a woman, that at young age, barely have a period or have irregular period?
Leanne Vogel: Yes. Either they had irregular period, and then probably started dieting.
Dr. Reiss Uzzi: That’s called a hypothalamic amenorrhea. The few reasons, you know we are in a society that you have an ounce, and especially here, an ounce of weight too much, you should be shameful. Lack of nutrient. It’s a big reason for hypothalamic amenorrhea, so you have to look at the nutritional approach. The thyroid is the main reason for hypothalamic amenorrhea. You have to look if it’s proper thyroid function. Too much of a hormone called prolactin can cause it. What I do, is two issue. The first issue is, this is a young woman that suffer from the same thing as women in menopause. They don’t have enough estrogen. They have declined in their brain function, bone function, heart function, skin, every system in their body deteriorates. They eyesight deteriorates. The hearing deteriorates. The vagina is not functional. Because she is young, it doesn’t mean that we don’t need to substitute it.
We have two choices. Either we’ll substitute it with bioidentical hormones. Obviously, the common mistake is to give birth control pill, and they have a period and they’re happy. Basically, we further have suppressed the situation. Another possibility is to do everything that you can to enhance the body to regulate itself. The interesting thing, estriol, one of the most incredible estrogen, that hardly is used unfortunately, I never give estradiol, the main estrogen we give without estriol. The only group I don’t give it, is women that have melasma, because estriol enhance the melasma. Estriol go up 1,000 time when women are pregnant. That’s why a lot of pregnant women have melasma.
If you give estriol alone, many time, that it’s incredible trigger for the hypothalamic area to start to work. Also, as I said before, adding estrogen don’t make your brain more lazy to make more estrogen. On the other hand, enhance it to make more estrogen. Most young ladies do not have zero estrogen but have very little estrogen. If they do not ovulate and have normal amount of estrogen, they will not be hypothalamic amenorrheic. They will bleed like crazy. They’ll have water retention. They’ll have breast pain. Unless they’re very deficient in estrogen, I’ll give them just progesterone, because sometimes giving progesterone for two week plus estriol trigger the endocrine system to work better.
Something else, I always give them melatonin. Melatonin improve your endocrine system. I make sure that their prolactin is low, because prolactin can suppress, again, the endocrine system. They either will be replaced just with progesterone, or with estrogen, estriol, and progesterone. By the way, every one of those women, you have to look if they have some symptomatology of polycystic ovary. If polycystic ovary 50 years ago was very rare event, and it used to be called Stein-Leventhal syndrome, those women look like very unappealing men. Today you can have beautiful woman with beautiful skin, without acne, with a lot of hair, and she has a lot of the characteristic of polycystic ovarian syndrome. We know today, that it’s coming from chemical, from plastic that their mother had taken when she was pregnant, is one of the main reasons.
If you have symptomatology of polycystic ovary, that’s another reason for irregular periods, and then we can do totally different things to enhance the period. We mainly concentrate in decreasing the insulin resistancy. We give them large dose of Inositol, and different type of Inositol that will enhance it. Again, as I said, you have to make sure that the thyroid is optimal, but the key, because she is young, it’s not okay that we keep her hormonal deficiency. It’s also the year that she has to learn to grow, to excel, to improve, and we need to completely replace them. Many of those girls, young girls, have human growth hormone deficiency. Also, a big problem today.
The level of human growth hormone in a population is 70 to 80% lower what we used to be. Many time I would stimulate the reappearance of a normal cyclicity with human growth hormone. They have such strong effect of everything in our brain function.
Leanne Vogel: Phenomenal. I know that everything that you’ve just shared is going to be so helpful, and I’m sure a lot of women listening are like, this man is amazing. How do I work with him? Where do I get support? Because you’re so knowledgeable and not everyone lives in LA.
Dr. Reiss Uzzi: I know. You know what, you get support. There’s two issue. There’s everywhere in United States, I think in … I would say, in any shopping center there’s a hormonal replacement, so there’s a lot of that. Not a lot of knowledge. They key issue when you come to have hormone replacement is, that most of the product that are given don’t work. 80% of the pharmaceutic product don’t give the minimum that you need to eliminate night sweats. I’m going to report in a lecture that I’m going to give that there’s two big study now, that they stop it. That was based on the patch, the patch is … do you know, the holy grail of chemical … of big pharma hormonal replacement, and they show it doesn’t give the minimum level that needed.
Only 15% of women that use the patch get the minimum that needed. They need to make sure that nobody determines from them what is enough. Nobody knows what is enough to you. You know what’s enough to you. If you take 12th grade today and look at the level of hormone in the 21st day of the cycle, it will range from 70 to 400, and nobody can determine what is right for you. You have to make sure when they give you a solution, so it’s very simple. Always three things are measure. The level of estrogen, that estradiol. Something called sex binding globulin that in charge of how much your body give to you, and how much your body hold from you, and the FSH. This is the follicle stimulate hormone. This is your brain tell you how much I think you have. When women are in fertility age, it’s under 10. When it go to 15, there’s already question if they can get pregnant. As they get more into perimenopause, it goes up. In menopause, it’s over 100, while their estrogen is zero.
Those three tools will let you know if you have enough estrogen. If somebody tell you, oh yes, your estrogen is 200, it’s too much, but the FSH is 40, your brain don’t think you have too much. Many time it’s because your sex binding globulin is higher than normal. Many time is a result of use of birth control pill, or estrogen in a pill form. That mean your body don’t give you what usually the body give. It give you much less. That’s why you need more. The key, when you’re given hormone anywhere, and you don’t feel right, you didn’t obtain back your vibration. Your smart thinking, your deep sleep, your motivation, your sexuality, your social skill, your happiness. You 99% don’t have enough estrogen, and so many product don’t give enough. By increasing the level of estrogen in these products, it wouldn’t work. You have to find other product that work better.
Leanne Vogel: Brilliant. I guess if you’re working with a doctor that maybe prescribes a chemical based hormone replacement therapy-
Dr. Reiss Uzzi: No, you shouldn’t work with a doctor that prescribe chemical. This an 18th-century approach. You know what? This is 18th century. By the way, one thing to say, a lot of women get a hysterectomy. I wouldn’t know why. The minute they get a hysterectomy, they say you don’t need progesterone. Why? Because they finally learned that the chemicalized progesterone is so viscous. Yes, you don’t need chemicalized progesterone, but the natural progesterone is not there only to protect you from cancer in the uterus that the estrogen alone does. Progesterone protects your brain, calms you, relax you, build your bone, take fluid out of you, decrease craving, decrease your anxiety, strongly protect you from breast cancer. This is something cardinal to be used with estrogen, and not only then, but there is also a secret subliminal formula that the progesterone protect your body from utilizing the estrogen wrong.
Leanne Vogel: Amazing. I think that a lot of the things that you said can also help people find a doctor, support … would you recommend that somebody just Google bioidentical hormone?
Dr. Reiss Uzzi: You find it from friend, from people that have gotten it. From people story. You might be talking to your general physician that have experience. You ask around. You go by yourself. You don’t listen to any bullshit. You want to see result. When you’re given the right balance of hormone in a short period, you go from being depressed, flat, uninspired, motivated, don’t care, don’t sleep, don’t retain, don’t retrieve, not sexual, to somebody that is visible, happy, inspired, motivated, remember, retain information, retrieve information. See significant change in his body, skin, sexual empower, motivated. There’s no two way, you either have enough hormone, or you don’t have.
Leanne Vogel: Brilliant. Is there anything else that you want to end our recording on? Anything else that you feel like we didn’t cover?
Dr. Reiss Uzzi: Okay. I’ll tell you just one thing.
Leanne Vogel: Okay.
Dr. Reiss Uzzi: This month I had … you see, the most expensive organ is our skin. In my building here in Beverly Hill, the plastic surgeon, they’re charging $250,000 for facelift. They’re doing incredible job, and people from all over the world, but your bioidentical hormone is the best facelift ever. I see this month, first, a woman that I was taking care of her for about 20 years. Between from the South, the mom died from breast cancer; they came to me about 20 years ago. One has every symptom in the book, said I’m going to take hormone, I don’t care. I try to reassure her. The other one had no symptom, said, unless you guarantee me that I would not get breast cancer, I won’t take it.
Fine. One took it. The other one didn’t take it. Months ago, this woman come to me, but she come with an old lady. I said, you know what, I’m so sorry, I’m so happy to see that your mom is alive. I was always sure that she was dead. She look at me, and say, I’m her sister. She got breast cancer. Not to say, that she didn’t take hormone she got breast cancer, but this horrendous difference. The look, the expression, the skin, the brightness. I never seen something so drastic, but here were 20 years of not taking hormone have done.
Then I seen another lady, she’s 85. I haven’t seen her for four years. I treated her since ’83. She comes and tells me there was reason why she couldn’t come to you. She always looks flawless. The last time I saw her, she was like 81, she looked beautiful. The skin, there barely any wrinkle. I always told her, when I grow old I want to look like you. Here she comes. I’m very naive, I’m not political. She came in, she asked, do you know who I am? I say, I’m not sure, but I think a few years ago I saw your daughter. She aged so much for four years, using the hormone, by the way, that was not sufficient. The deterioration was so fast of a skin quality without hormone, but on the other hand, the build up of functional skin that is full. Full of rigor, with redness, with a lot of elastin and collagen, and buildup of the muscle under three. This is what estrogen will give to you.
I can sit and talk all day long, but …
Leanne Vogel: Right? I know, and I’m so interested in hormones. As somebody that’s had such a difficult hormone-
Dr. Reiss Uzzi: The last thing that I would say. I absolutely resent the idea that women with breast cancer should not take estrogen, but this is a long discussion by itself.
Leanne Vogel: Well, another conversation for another time. I’d love to have you on the show again.
Dr. Reiss Uzzi: Yes. Thank you very much.
Leanne Vogel: Yeah, thanks so much for coming on. If anyone wants Dr. Reiss Uzzi’ book, I will include a link in the show notes, which you can find at healthfulpursuit.com/podcast/e8. Thanks so much for being on the show.
Dr. Reiss Uzzi: Thank you.
Leanne Vogel: That does it for another episode of The Keto Diet Podcast. Thanks for listening in. You can follow me on Instagram by searching healthful pursuit, where you’ll find daily keto eats, and other fun things. Check out all of my keto supportive programs, bundles, guides, and other cool things over at healthfulpursuit.com/shop, and I’ll see you next Sunday. Bye.