Perimenopause, Why Your Old Plan Stopped Working And What To Do Now

November 18, 2025 By Leanne Vogel November 18, 2025

Hey friend, I am glad you are here. If your sleep is off, your mood feels unpredictable, and your metabolism is not playing fair, you are not alone. You might be eating like you always have and even pushing harder at the gym, yet the scale creeps up. Energy is great one day and gone the next.

This is perimenopause. It can begin in the mid-30s and it affects every system, not only your cycle. Estrogen and progesterone do not simply decline, they fluctuate. Some days you feel like yourself, other days you wonder what changed. These shifts touch brain chemistry, blood sugar, sleep cycles, muscle, and stress tolerance.

You are not broken. You are experiencing biology. In this post we will make sense of the changes and show how bioactive peptides, plus simple nutrition, movement, stress, and sleep practices, can help you feel steady again.

Why Perimenopause Feels Like A Rollercoaster

Perimenopause is puberty in reverse. Hormones do not move in a straight line. They swing.

What that looks like in daily life:

Sleep changes. Progesterone supports GABA, the calming system in the brain. When progesterone dips, sleep fragments and 2 to 3 a.m. wakeups show up.
Mood swings. Estrogen influences serotonin and dopamine. Fast rises or drops can feel like anxiety, irritability, or tears.
Metabolism slows. Estrogen helps maintain muscle and insulin sensitivity. With fluctuation, muscle breaks down faster, midsection fat increases, and cravings get louder.
Stress feels heavier. The HPA axis becomes more sensitive. Cortisol rises faster and stays higher, so small stressors feel bigger.
Body signals shift. Drier skin, slower digestion, achier joints. Estrogen receptors live in the brain, bones, gut, and skin, so many systems notice the change.

You cannot out-diet or out-exercise this phase. That is not failure. It is a cue to support your biology in a new way.

The Science Of Peptides And How They Help

Peptides are short chains of amino acids that act like messages your cells understand. They bind to receptors and nudge processes that have gone quiet. They do not override your body.

They remind it.

Examples of what certain bioactive peptides support:

Muscle repair and growth by stimulating protein synthesis pathways like mTOR.
Neurotransmitter balance that steadies serotonin and dopamine for calmer mood and better focus.
Insulin sensitivity and glucose use for fewer crashes and fewer cravings.
Mitochondrial function for steadier daily energy.

MAKE uses plant-derived, bioactive peptides designed for oral use. A protective protein-peptide matrix helps them stay intact through digestion so they reach target tissues.

Just LOOK at these ladies making shifts:

The Most Helpful Peptides For Perimenopause

LEAN
For cravings and midsection fat. LEAN supports leptin and insulin signaling along the gut-brain axis. The result is fewer snack attacks and a metabolism that uses fuel more efficiently, without stimulants and without muscle loss.
Get LEAN here

FIT
For muscle, strength, and recovery. Estrogen normally protects lean tissue. FIT supports protein synthesis so workouts work again, soreness fades faster, and metabolism stays responsive.
Get FIT here

CALM
For stress and sleep. CALM supports GABA and balances cortisol. Many women describe it as nervous system nourishment, with easier sleep onset and fewer 3 a.m. wakeups.
Get CALM here

FOCUSED
For brain fog and mental stamina. FOCUSED supports neuronal signaling and mitochondrial energy in the brain. Expect clearer recall, better attention, and less screen fatigue.
Get FOCUSED here

HYDRATED
For cellular hydration. Estrogen shifts fluid balance. HYDRATED combines electrolytes with glycine for deeper hydration and better transport of nutrients and peptides.
Get HYDRATED here

NOT SURE WHICH IS BEST FOR YOU?

Why I Recommend MAKE

Plant-based and bioactive. No hormones, no animal byproducts, no artificial additives.
Targeted by design. The sequences are selected to fit specific receptors so the signal is clear and efficient.
Built for women in this season. Formulas match common perimenopause needs: metabolism, mood, brain fog, sleep, hydration, and recovery.
Convenient and consistent. Oral, quick to take, easy to keep up with.

Start your peptide journey

Subscribers get access to me via text (like this) for any peptide support they need. Plus, we do monthly group calls (education, giveaways, Q&A) so it’s a grand ‘ol time over here!

Integration, Peptides Plus Lifestyle That Works Now

Peptides are amplifiers. The foundation still matters.

Nutrition. Protein needs rise in perimenopause. Center meals on protein, add fiber-rich carbs and healthy fats to steady blood sugar. Magnesium, zinc, and B vitamins support hormone metabolism and the nervous system.

Movement. Strength training protects muscle and bone. Keep walking for heart health and recovery. Balance intensity with rest so cortisol does not run the show.

Stress and sleep. Short resets count. Breathwork, light mobility, or a 10 minute walk can lower cortisol. Keep the room cool and dark, power down screens before bed, and consider magnesium or glycine if needed.

Environment. Reduce fragrance, plastics, and pesticide exposure when possible. Less noise for your hormones to process means faster progress.

When you pair peptides with these basics, you get compounding wins. Workouts produce results again. Cravings quiet down. Mood steadies. Sleep restores.

Get started on peptides (use code GIVE10 for $10 off)

How To Start Without Overwhelm

Start simple and build only if needed.

FIT plus HYDRATED as your base for two weeks.
Add LEAN if your main goal is fat loss and appetite control.
Add CALM if stress and sleep are the loudest issues.
Add FOCUSED or ENERGIZED later if daytime clarity or drive still needs support.

LET ME HELP YOU CHOOSE YOUR PEPTIDE STACK

Most women feel a shift within 7 to 10 days. Results compound across 4 to 8 weeks.